Triptorelin GnRH 100mcg
Triptorelin GnRH for sale is available in lyophilized powder form, in 100mcg vials.
About Triptorelin: Triptorelin is a synthetic gonadotropin-releasing hormone (GnRH) peptide agonist that binds to the GnRH receptor (GnRHR; Ki = 0.3 nM in CHO cells expressing the human receptor).1 It inhibits the growth of DU145, LNCaP, and PC3 prostate and OVCAR-3 ovarian cancer cells (IC50s = 62.1, 73.4, 98.1, and 67.7 μM, respectively).2 Triptorelin also inhibits the growth of the triple-negative breast cancer (TNBC) cell lines HCC1806 and MDA-MB-231 (EC50s = 58.29 and 31.59 μM, respectively).3 It stimulates follicle stimulating hormone (FSH) and luteinizing hormone (LH) release from primary rat pituitary cells when used at a concentration of 50 nM.2 It also decreases tumor volume of Dunning R3327H prostate tumor flank implants and reduces prostate and testis weight in rats when administered at a dose of 1 mg/kg per day.4 Formulations containing triptorelin have been used in the palliative treatment of advanced prostate cancer.
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We offer the highest grade and purity of triptorelin for sale at a competitive price in the USA. For best results buy triptorelin peptides of the highest quality from GenX Peptides.
For more information on Triptorelin peptide please visit Pubmed.
References & Product Citations
Product Description References
1. Nederpelt, I., Georgi, V., Schiele, F., et al. Characterization of 12 GnRH peptide agonists – a kinetic perspective. Br. J. Pharmacol. 173(1), 128-141 (2016).
2. Varamini, P., Rafiee, A., Giddam, A.K., et al. Development of new gonadotropin-releasing hormone-modified dendrimer platforms with direct antiproliferative and gonadotropin releasing activity. J. Med. Chem. 60(20), 8309-8320 (2017).
3. Kwok, C.W., Treeck, O., Buchholz, S., et al. Receptors for luteinizing hormone-releasing hormone (GnRH) as therapeutic targets in triple negative breast cancers (TNBC). Target Oncol. 10(3), 365-373 (2015).
4. Princivalle, M., Broqua, P., White, R., et al. Rapid suppression of plasma testosterone levels and tumor growth in the dunning rat model treated with degarelix, a new gonadotropin-releasing hormone antagonist. J. Pharmacol. Exp. Ther. 320(3), 1113-1118 (2007).
|Unit Size||100 mcg/vial|
|Unit Quantity||1 Vial|
|Solubility||>Soluble in water or 1% acetic acid|
|Storage||Lyophilized GnRH Triptorelin is stable at room temperature for 90 days, however it should be stored in a freezer below -8C for any extended period of time.|
|Safety Information||For Research Only. Not Intended for Diagnostic or Therapeutic Use.|
|Dimensions||1 × 1 × 1 in|