IGF-1 LR3 (Receptor Grade) 1mg

What is IGF1-LR3?

LR3-IGF-I, Human (Receptor Grade) is a Human Recombinant, single, non-glycosylated, polypeptide chain containing 83 amino acids. It is an analog of human IGF-1 comprising the complete human IGF-1 sequence with the substitution of an Arginine (Arg or R) for the Glutamic Acid (Glu or E) at position 3 (hence R3), and a 13 amino acid extension peptide at the N-terminus.

• IGF1 LR3 is an analogue of human IGF-1 that has been modified to include a 13 amino acid N-terminus extension and the substitution of Arginine for Glutamic Acid at position 3.
• As a result of these modifications, IGF-1 LR3 is approximately three times more potent than IGF-1 and possesses an increased half-life due to lowered affinity for binding to the Insulin-Like Growth Factor Binding Proteins (IGFBPs).
• IGFLR3 retains the ability to bind agonistically to the IGF–1 receptor with improved metabolic stability, relative to IGF–1.
• The supplementation of mammalian cell cultures with Long R3 IGF1 at a much lower concentration results in more highly elevated productivity than with standard concentrations of insulin and/or standard IGF1.
• IGF-LR3 is able to stimulate the type 1 IGF receptor and thus induce a higher level of activation of intracellular signaling , which is responsible for promoting cell proliferation and the inhibition of apoptosis .

This analog has been engineered with the express purpose of increasing biological activity. IGF-1 Long[R3] is significantly more potent than IGF-1 in vitro and in vivo. The enhanced potency is due to the markedly decreased binding of IGF-1 Long[R3] to all IGF binding proteins. These binding proteins normally inhibit the biological actions of IGFs.

IGF-1 stands for insulin-like growth factor. It is a natural substance that is produced and is at its highest natural levels during puberty. During puberty IGF-1 is the most responsible for the natural muscle growth that occurs during these few years.

Common benefits of IGF-1 LR3 include:

increased amino acid transport to cells

increased glucose transport

increased protein synthesis

decreased protein degradation

increased RNA synthesis

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We offer the highest grade and purity of IGF1 LR3 for sale at a competitive price in the USA. For best results buy IGF-1 LR3 of the highest quality from GenX Peptides.

For more information on IGF-1 LR3 peptide please visit Pubmed.

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