PT-141 10mg

PT-141 Peptide Description

PT-141 is a synthetic peptide compound developed by Palatin Technologies and it is mainly used as a treatment for female sexual dysfunction (FSD), male erectile dysfunction (ED), hemorrhagic shock and reperfusion injury. Preclinical studies have demonstrated that PT-141 significantly enhances sexual behavior in female mice.

How does PT 141 work?

Bremelanotide increases sexual desire through the activation in the brain of the MC4 receptor, which regulates the metabolism, the sexual behavior, and the male erectile function. Its operating mechanism involves an action in the central nervous system rather than directly on the vascular system.

Mechanism of Action and PT-141 Results

Initial testing, PT-141 was conceived as a sunless tanning agent and had its origins from the Melanotan II peptide hormone, which is a synthetic analog of the naturally occurring melanocortin peptide hormone that is used to produce melanogenesis (the production of a pigment found in the skin, eyes, and hair called melanin). Nevertheless, Bremelanotide has subjective measurements of sexual arousal and spontaneous male erections during testing, which showed the potential of this peptide as an effective treatment of sexual dysfunction in both men and woman for vaginal pulse amplitude with reported high sexual desire following bremelanotide.

Administration of PT-141 to rats and nonhuman primates results in penile erections. Systemic administration of PT-141 to rats activates neurons in the hypothalamus as shown by an increase in c-Fos immunoreactivity. Neurons in the same region of the central nervous system take up pseudorabies virus injected into the corpus cavernosum of the rat penis. In men, PT-141 works as a treatment for erectile dysfunction (the inability to develop or maintain an erection of the penis during sexual activity). An erection is accomplished while blood enters and is retained in sponge-like bodies within the penis because of sexual arousal. Due to the brain is in charge of transmitting signals to nerves in the penis, the stimulation of this process causes an erection through the use of PT-141.

PT-141 is an effective treatment for arousal disorder, which is characterized by the lack or absence of desire for sexual activity in a situation that would normally produce a response to the stimulus. This disorder can be caused physically because of circulatory problems or alterations in neurological functions where low levels of libido (desire for sexual activity) are observed. Libido is regulated both by the sex hormones and the associated neurotransmitter that act upon testosterone and dopamine.

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For more information on PT141 peptide please visit Pubmed.

References:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2694735/

https://pubmed.ncbi.nlm.nih.gov/12851303/

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