Thymosin Alpha-1 3mg

$44.99

Thymosin Alpha-1 for sale which is available in lyophilized powder peptide form, in 3mg vials.

In stock

SKU: thymosin-alpha-1 Category: Tag:

Description

About Thymosin Alpha-1: Thymosin Alpha 1 restores immune function and regulates the immune response improving your immune health. Thymosin α1 is a cationic and α-helical antimicrobial peptide expressed in human bone marrow, testis, granulocytes, and gingival epithelium and is upregulated in psoriatic lesions.1 It inhibits growth of Gram-positive E. coli D21 and Gram-negative B. megatarium in a concentration-dependent manner and LL-37 expression is induced in A549 epithelial cells, alveolar macrophages, neutrophils, and monocyte-derived macrophages following M. tuberculosis infection.1,2,3 LL-37 binds sheep erythrocytes coated with S. minnesota Re-LPS and induces agglutination with a minimal agglutinating concentration (MAC) of 12.1 μg/ml.4

It is a chemoattractant for, and can induce calcium mobilization in, human monocytes, neutrophils, and T cells that naturally express formyl peptide receptor-like 1 (FPRL1) and FPRL1-transfected HEK293 cells.5 LL-37 (10-15 μM) pretreatment of dengue virus type 2 (DENV-2) reduces its infectivity as well as levels of viral genomic RNA and NS1 antigen.6In vivo, LL-37 inhibits cecal ligation and puncture-induced caspase-1 activation and pyroptosis of peritoneal macrophages, reduces levels of the inflammatory cytokines IL-1β, IL-6, and TNF-α, and improves survival in polybacterial septic mice.7

Buy Thymosin Alpha 1 online today from GenX Peptides.

We offer the highest grade and purity of Thymosin Alpha-1 for sale at a competitive price in the USA. For best results buy thymosin alpha 1 of the highest quality from GenX Peptides.

For more information on thymosin alpha-1 peptide please visit Pubmed.

References & Product Citations

Product Description References

1. Manrow, R.E., Leone, A., Krug, M.S., et al. The human prothymosin α gene family contains several processed pseudogenes lacking deleterious lesions. Genomics 13(2), 319-331 (1992).

2. Binsfeld, M., Hannon, M., Otjacques, E., et al. Impact of the immunomodulating peptide thymosin alpha 1 on multiple myeloma and immune recovery after hematopoietic stem cell transplantation. Cancer Immunol. Immunother. 64(8), 989-998 (2015).

3. Bo, C., Wu, Q., Zhao, H., et al. Thymosin α1 suppresses migration and invasion of PD-L1 high-expressing non-small-cell lung cancer cells via inhibition of STAT3-MMP2 signaling. Onco. Targets Ther. 11, 7255-7270 (2018).

4. Romani, L., Oikonomou, V., Moretti, S., et al. Thymosin α1 represents a potential potent single-molecule-based therapy for cystic fibrosis. Nat. Med. 23(5), 590-600 (2017).

Unit Size3 mg/vial (Without a label, purple caps)
Unit Quantity1 Vial
Molecular FormulaC129H215N33O55
Molecular Weight3108.3
SequenceAc-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH
AppearanceWhite Powder
Peptide Purity>99%
SolubilitySoluble in water or 1% acetic acid
SourceChemical Synthesis
StorageLyophilized thymosin alpha-1 is stable at room temperature for 90 days. However, it should be stored in a freezer below -8C for any extended period.
Safety InformationFor Research Only. Not Intended for Diagnostic or Therapeutic Use. 

 

 

Additional information

Weight1 oz
Dimensions1 × 1 × 1 in
buy thymosin alpha 1
Thymosin Alpha-1 3mg
$44.99
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