Thymosin Alpha-1 3mg
Thymosin Alpha-1 for sale which is available in lyophilized powder peptide form, in 3mg vials.
About Thymosin Alpha-1: Thymosin Alpha 1 restores immune function and regulates the immune response improving your immune health. Thymosin α1 is a cationic and α-helical antimicrobial peptide expressed in human bone marrow, testis, granulocytes, and gingival epithelium and is upregulated in psoriatic lesions.1 It inhibits growth of Gram-positive E. coli D21 and Gram-negative B. megatarium in a concentration-dependent manner and LL-37 expression is induced in A549 epithelial cells, alveolar macrophages, neutrophils, and monocyte-derived macrophages following M. tuberculosis infection.1,2,3 LL-37 binds sheep erythrocytes coated with S. minnesota Re-LPS and induces agglutination with a minimal agglutinating concentration (MAC) of 12.1 μg/ml.4
It is a chemoattractant for, and can induce calcium mobilization in, human monocytes, neutrophils, and T cells that naturally express formyl peptide receptor-like 1 (FPRL1) and FPRL1-transfected HEK293 cells.5 LL-37 (10-15 μM) pretreatment of dengue virus type 2 (DENV-2) reduces its infectivity as well as levels of viral genomic RNA and NS1 antigen.6In vivo, LL-37 inhibits cecal ligation and puncture-induced caspase-1 activation and pyroptosis of peritoneal macrophages, reduces levels of the inflammatory cytokines IL-1β, IL-6, and TNF-α, and improves survival in polybacterial septic mice.7
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For more information on thymosin alpha-1 peptide please visit Pubmed.
References & Product Citations
Product Description References
1. Manrow, R.E., Leone, A., Krug, M.S., et al. The human prothymosin α gene family contains several processed pseudogenes lacking deleterious lesions. Genomics 13(2), 319-331 (1992).
2. Binsfeld, M., Hannon, M., Otjacques, E., et al. Impact of the immunomodulating peptide thymosin alpha 1 on multiple myeloma and immune recovery after hematopoietic stem cell transplantation. Cancer Immunol. Immunother. 64(8), 989-998 (2015).
3. Bo, C., Wu, Q., Zhao, H., et al. Thymosin α1 suppresses migration and invasion of PD-
4. Romani, L., Oikonomou, V., Moretti, S., et al. Thymosin α1 represents a potential potent single-
|Unit Size||3 mg/vial
|Unit Quantity||1 Vial|
|Solubility||Soluble in water or 1% acetic acid|
|Storage||Lyophilized thymosin alpha-1 is stable at room temperature for 90 days. However, it should be stored in a freezer below -8C for any extended period.|
|Safety Information||For Research Only. Not Intended for Diagnostic or Therapeutic Use.|
|Dimensions||1 × 1 × 1 in|