Thymosin Alpha-1 3mg
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Thymosin Alpha 1 Description
About Thymosin Alpha-1: Thymosin Alpha 1 restores immune function and regulates the immune response improving your immune health. Thymosin α1 is a cationic and α-helical antimicrobial peptide expressed in human bone marrow, testis, granulocytes, and gingival epithelium and is upregulated in psoriatic lesions.1 It inhibits growth of Gram-positive E. coli D21 and Gram-negative B. megatarium in a concentration-dependent manner and LL-37 expression is induced in A549 epithelial cells, alveolar macrophages, neutrophils, and monocyte-derived macrophages following M. tuberculosis infection.1,2,3 LL-37 binds sheep erythrocytes coated with S. minnesota Re-LPS and induces agglutination with a minimal agglutinating concentration (MAC) of 12.1 μg/ml.4
It is a chemoattractant for, and can induce calcium mobilization in, human monocytes, neutrophils, and T cells that naturally express formyl peptide receptor-like 1 (FPRL1) and FPRL1-transfected HEK293 cells.5 LL-37 (10-15 μM) pretreatment of dengue virus type 2 (DENV-2) reduces its infectivity as well as levels of viral genomic RNA and NS1 antigen.6In vivo, LL-37 inhibits cecal ligation and puncture-induced caspase-1 activation and pyroptosis of peritoneal macrophages, reduces levels of the inflammatory cytokines IL-1β, IL-6, and TNF-α, and improves survival in polybacterial septic mice.7
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For more information on thymosin alpha-1 peptide please visit Pubmed.
References & Product Citations
Product Description References
1. Manrow, R.E., Leone, A., Krug, M.S., et al. The human prothymosin α gene family contains several processed pseudogenes lacking deleterious lesions. Genomics 13(2), 319-331 (1992).
2. Binsfeld, M., Hannon, M., Otjacques, E., et al. Impact of the immunomodulating peptide thymosin alpha 1 on multiple myeloma and immune recovery after hematopoietic stem cell transplantation. Cancer Immunol. Immunother. 64(8), 989-998 (2015).
3. Bo, C., Wu, Q., Zhao, H., et al. Thymosin α1 suppresses migration and invasion of PD-
4. Romani, L., Oikonomou, V., Moretti, S., et al. Thymosin α1 represents a potential potent single-
Lyophilized thymosin alpha-1 peptide is stable at room temperature for 90 days. However, it should be stored in a freezer below -8C for any extended period.
For Research Only. Not Intended for Diagnostic or Therapeutic Use
Products on the website are not intended for use in the diagnosis, cure, mitigation, treatment, or prevention of disease and are not intended to affect the structure or any function of the body. The use of our products are for only research/laboratory purposes.
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