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MOTS-c 5mg

5.00 out of 5
(6 customer reviews)


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MOTS-c is a novel mitochondrial-derived peptide from the mitochondrial protein that is responsible for the synthesis of ATP. It also has been shown to significantly increase insulin sensitivity and can decrease the amount of glucose that is broken down by adipose cells. It has also been shown to reduce fatty liver disease, and there have also been numerous studies to show how effective this peptide is in possibly aiding with diabetes This specific peptide has shown to be able to promote a positive shift in insulin sensitivity, where exercise and diet can lead to muscles regaining their normal function. This decreases the levels of insulin and leptin resistance [4].

Additionally, it has been found that levels of insulin resistance and glucose tolerance are significantly reduced. More importantly, studies have shown that MOTS-C has the ability to improve the function of the beta islet cells, which are responsible for the production of insulin. This presents a potential mechanism for the treatment of Type 2 Diabetes. Another study examined the effects of MOTS-C on lean mass, body fat mass, and fat-free mass. It was concluded that MOTS-C significantly increased lean mass and did not have any negative effects on fat mass or fat-free mass [5]. In short, MOTS-C is a peptide that can be used to treat diabetes and Alzheimer’s, significantly improve insulin sensitivity, and reduce body fat levels in animal models.

MOTS-c is a 16 amino acid peptide that regulates insulin sensitivity and metabolic homeostasis. Its primary target organ appears to be the skeletal muscle and its cellular actions inhibit the folate cycle and its tethered de novo purine biosynthesis, leading to AMPK activation. MOTS-c treatment in mice prevented age-dependent and high-fat diet-induced insulin resistance, as well as diet-induced obesity. MOTS-c is a mitochondrial peptide with diverse biological activities.1,2,3

It increases osteogenic differentiation and the formation of calcified nodules in rat bone mesenchymal stem cells (BMSCs) when used at a concentration of 1 µM.1 MOTS-c decreases 5-methyl-tetrahydrofolate levels, blocking de novo purine biosynthesis, increases accumulation of 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR), and activates AMPK in HEK293 cells.2 It increases glycolysis in HEK293 cells in an AMPK-dependent manner. In vivo, MOTS-c (0.5 mg/kg per day, i.p.) increases glucose clearance in mice fed a normal diet. It increases skeletal muscle AMPK activation and GLUT4 expression, as well as prevents high-fat diet-induced obesity and hyperinsulinemia in CD-1 mice. MOTS-c (5 mg/kg) increases AMPK activation, reduces protein levels of the angiotensin II type 1 (AT1) and endothelin B (ETB) receptors and left ventricular posterior wall thickness, and attenuates aortic calcification in a rat model of secondary myocardial remodeling.3

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We offer the highest grade and purity of MOTS-c for sale at a competitive price in the USA. For best results buy MOTS-c of the highest quality from GenX Peptides.

For more information on MOTS-c peptide please visit Pubmed.


References & Product Citations

Product Description References

1. Hu, B.-T., and Chen, W.-Z. MOTS-c improves osteoporosis by promoting osteogenic differentiation of bone marrow mesenchymal stem cells via TGF-β/Smad pathway. Eur. Rev. Med. Pharmacol. Sci. 22(21), 7156-7163 (2018).

2. Lee, C., Drew, B.G., Sallam, T., et al. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metabolism 21(3), 443-454 (2015).

3. Wei, M., Gan, L., Liu, Z., et al. Mitochondrial-derived peptide MOTS-c attenuates vascular calcification and secondary myocardial remodeling via adenosine monophosphate-activated protein kinase signaling pathway. Cardiorenal. Med. 10(1), 42-50 (2020).



Product Name


Unit size


Molecular Formula


Molecular Weight

2174.6 g/mol


Mitochondrial open reading frame of the 12S rRNA-c


White Powder

Peptide Purity



Chemical Synthesis


Lyophilized mots-c peptide is stable at room temperature for 90 days. However, it should be stored in a freezer below -8C for any extended period of time

Safety Information

For Research Only. Not Intended for Diagnostic or Therapeutic Use

Products on the website are not intended for use in the diagnosis, cure, mitigation, treatment, or prevention of disease and are not intended to affect the structure or any function of the body. The use of our products are for only research/laboratory purposes.

Additional information

Weight1 oz
Dimensions1 × 1 × 2 in

6 reviews for MOTS-c 5mg

  1. 5 out of 5

    Charlotte (verified owner)

    Thank you very much… Charlotte

  2. 5 out of 5

    Warren S. (verified owner)

    usNew York, United States

  3. 5 out of 5

    Steven H. (verified owner)

    usMissouri, United States


  4. 5 out of 5

    Peter C. (verified owner)

    usUnited States

    Fast shipping, everything was packed nice and the product works as expected!

  5. 5 out of 5

    Raul Rodriguez (verified owner)

    Great stuff

  6. 5 out of 5

    Amy (verified owner)

    Great product!

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MOTS-c 5mg Peptide Vial For Sale
MOTS-c 5mg