LL-37 5mg (CAP-18)
$79.99
Buy LL-37 for sale which is available in lyophilized powder peptide form, in 5mg vials.
In stock
Description
About LL-37: LL-37 is a cationic and α-helical antimicrobial peptide expressed in human bone marrow, testis, granulocytes, and gingival epithelium and is upregulated in psoriatic lesions.1 It inhibits growth of Gram-positive E. coli D21 and Gram-negative B. megatarium in a concentration-dependent manner and LL-37 expression is induced in A549 epithelial cells, alveolar macrophages, neutrophils, and monocyte-derived macrophages following M. tuberculosis infection.1,2,3 LL-37 binds sheep erythrocytes coated with S. minnesota Re-LPS and induces agglutination with a minimal agglutinating concentration (MAC) of 12.1 μg/ml.4
It is a chemoattractant for, and can induce calcium mobilization in, human monocytes, neutrophils, and T cells that naturally express formyl peptide receptor-like 1 (FPRL1) and FPRL1-transfected HEK293 cells.5 LL-37 (10-15 μM) pretreatment of dengue virus type 2 (DENV-2) reduces its infectivity as well as levels of viral genomic RNA and NS1 antigen.6In vivo, LL-37 inhibits cecal ligation and puncture-induced caspase-1 activation and pyroptosis of peritoneal macrophages, reduces levels of the inflammatory cytokines IL-1β, IL-6, and TNF-α, and improves survival in polybacterial septic mice.7
Buy LL-37 cathelicidin antimicrobial peptide online today from GenX Peptides.
We offer the highest grade and purity of LL-37 for sale at a competitive price in the USA. For best results buy LL-37 peptides of the highest quality from GenX Peptides.
For more information on LL-37 peptide please visit Pubmed.
References & Product Citations
Product Description References
1. Epithelial antimicrobial peptides: Review and significance for oral applications. Crit. Rev. Oral Biol. Med. 9(4), 399-414 (1998).
2. Expression of cathelicidin LL-
3. The human gene FALL39 and processing of the cathelin precursor to the antibacterial peptide LL-
4. Human CAP18: A novel antimicrobial lipopolysaccharide-
5. LL-
6. In-
7. Antimicrobial cathelicidin peptide LL-
| Unit Size | 5 mg/vial |
| Unit Quantity | 1 Vial |
| Molecular Formula | C205H340N60O53 |
| Molecular Weight | 4493.3 |
| Sequence Shortening | LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES |
| Appearance | White Powder |
| Peptide Purity | >99% |
| Solubility | Insoluble in water. Dissolve the peptide in 10% acetonitrile with 0.1% TFA solution. Further dilute with desired buffer. |
| Source | Chemical Synthesis |
| Storage | Lyophilized LL-37 is stable at room temperature for 90 days. However, it should be stored in a freezer below -8C for any extended period. |
| Safety Information | For Research Only. Not Intended for Diagnostic or Therapeutic Use. |
Additional information
| Weight | 1 oz |
|---|---|
| Dimensions | 1 × 1 × 2 in |
