Ipamorelin 2mg

Ipamorelin is a pentapeptide (Aib-His-D-2-Nal-D-Phe-Lys-NH2) and a ghrelin mimetic with growth hormone secretagogue receptor (GHS), which significantly increases plasma growth hormone (GH) levels in both humans and animals. Ipamorelin has distinct and specific growth hormone (GH)-releasing properties because it also stimulates the production of IGF-1 in the liver independent of GH levels. This means that ipamorelin has the ability to be more potent to stimulate systems related to growth and repair.

Mechanism of Action

Ipamorelin Peptide binds to GHSRs (also called as Growth hormone secretagogue receptors) due to its agonist property to activate it in the search for a biological response. This receptor is located in the hypothalamic ventromedial nucleus of the brain and it is in charge of the production of energy homeostasis (that enhance the regulation of caloric intake by signaling the brain to regulate the sensation of hunger) and the regulation of body weight.

Scientifically Investigated Possible Benefits of Ipamorelin

Unlike other peptides, Ipamorelin peptide does not affect prolactin, which is a protein secreted by the pituitary gland in response to eating, mating, estrogen treatment, ovulation, and nursing. It enables the production milk of mammals and it regulates the immune system as well as the pancreatic development.

Scientific studies observed no adverse effects have been reported both in Follicle-Stimulating Hormone (FSH) as in Luteinizing hormone (LH). FSH and LH cause the release of ovulation through the stimulation of the ovaries in laboratory mice, and they contribute to produce testosterone and sperm through the stimulation of the testicles in male laboratory mice.

No effect has been reported Thyroid-Stimulating Hormone (TSH) during the use of Ipamorelin. This is important because TSH plays an important role in the stimulation of the metabolism of almost every tissue; it regulates the endocrine function of the thyroid that stabilizes the level of thyroid hormones avoiding an excessive production that can cause hyperthyroidism and the deficiency of the same hormones leading to hypothyroidism.

Ipamorelin does not stimulate the secretion of Adrenocorticotropic Hormone (ACTH) that is produced on the anterior pituitary gland. ACTH is stimulated by biological stress and can increase the production of cortisol (depressing the immune system). Elevated ACTH levels could be caused by adrenal insufficiency, which is a lack of production of adequate amounts of steroid hormones like cortisol. [1]

There are no reports of cortisol affections caused by Ipamorelin. As it mentioned above cortisol is in charge of maintaining an adequate balance of the insulin by keeping optimal levels of sugar in the blood, as well as the use of sugar and fat to obtain energy. It also contributes to control and respond to stress (mice suffering chronic stress and depression has shown high levels of cortisol). Cortisol regulates the blood pressure (avoiding alterations to the heart, the kidney, the vision, the sexual performance, the memory, and the arterial function) and the immune system.

Ipamorelin hormone usage encourages weight loss by reducing hunger while simultaneously building muscle, although further research needs to be conducted. Clinical trials by qualified researchers have indicated that Ipamorelin is generally well-tolerated. However, some undesirable effects resulting from high levels of GH and IGF-1 in the blood may still be possible. 

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[1] https://pubmed.ncbi.nlm.nih.gov/9849822/

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