PE-22-28

PE-22-28 is a spadin derivative that exhibits an improved specificity and affinity for TREK-1 channel compared to spadin. PE-22-28 is a synthetic fast-acting peptide that may treat depression better than other TREK-1 blocking antidepressants such as Cilatopram and Paroxetine. PE-22-28 may have the potential to be an impressive compound to treat depression by comparing two studies of mice.

The first analysis study concluded, “In vivo, the antidepressant properties of PE 22-28 and its derivatives were demonstrated in behavioral models of depression, such as the forced swimming test. Mice treated with spadin-analogs showed a significant reduction of the immobility time. Moreover, in the novelty suppressed feeding test after a 4-day sub-chronic treatment PE 22-28 reduced significantly the latency to eat the food pellet”

The second application refers to TREK-1 inhibition rather than PE-22-28 itself, results corroborate the conclusion of the first study: “Knockdown of TREK-1 in hippocampal neurons significantly attenuated depressive-like behaviors and prevented the decrease of CUMS [chronic unpredictable mild stress] induced synaptic proteins in mice. Further examination indicated that neuron-specific knockdown of TREK-1 in the hippocampus prevented stress-induced impairment of glutamatergic synaptic transmission in the CA1 region. Moreover, chronic TREK-1 inhibition protected against CUMS-induced depressive-like behaviors and impairment of synaptogenesis in the hippocampus”. ¹

PE-22-28 may also be effective for treatment of stroke recovery, improved memory and learning.

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For more information on PE-22-28 peptide please visit Google Scholar.

References & Product Citations