CJC-1295 (without DAC) Peptide

What is CJC-1295 Modified GRF (1-29)?

CJC-1295 without DAC (Drug Affinity Complex), also known as Modified GRF (1-29), is a synthetic analog of growth hormone-releasing hormone (GHRH). It has been studied for its ability to stimulate the release of endogenous growth hormone (GH) from the pituitary gland, making it of significant interest for applications related to growth hormone deficiency, aging, and muscle-wasting conditions. This research description provides an overview of its structure, mechanism of action, and potential therapeutic applications, with references to key studies in the field.

Growth hormone (GH) is critical for regulating metabolism, cell growth, and tissue repair, and its secretion declines with age. The search for methods to stimulate GH production has led to the development of peptides that mimic natural GH-releasing hormone (GHRH). CJC-1295 No DAC, or Modified GRF (1-29), is one such peptide, designed to enhance the body’s natural release of growth hormone without the prolonged half-life associated with the DAC-modified version.

Chemical Structure

CJC-1295 No DAC is a modified version of GHRH, specifically the first 29 amino acids (1-29) of endogenous GHRH, which is known to be the most biologically active fragment. The modifications in the peptide sequence increase the peptide’s resistance to enzymatic degradation, thus enhancing its stability and biological activity. Unlike the DAC version, CJC-1295 No DAC does not include a drug affinity complex, meaning it has a shorter half-life but mimics more closely the natural pulsatile release of GH.

Mechanism of Action:

CJC-1295 No DAC binds to the GHRH receptor on somatotroph cells in the anterior pituitary, stimulating the secretion of GH. The peptide acts by increasing the amplitude of GH pulses rather than altering the frequency of secretion. This mechanism is thought to maintain a more natural secretion pattern, as compared to the continuous GH secretion induced by longer-acting peptides like CJC-1295 with DAC.

Advantages and Limitations:

Compared to its DAC-modified counterpart, CJC-1295 No DAC has a shorter half-life, which can be seen as both an advantage and a limitation. The shorter half-life allows for more precise control of GH pulsatility, which is closer to natural physiology, but may require more frequent dosing to maintain its effects.

The absence of the DAC component also reduces the risk of unwanted continuous GH release, which can lead to side effects like insulin resistance or acromegaly with long-term use. However, frequent administration could reduce patient compliance compared to longer-acting alternatives.

Conclusions:

CJC-1295 No DAC (Modified GRF (1-29)) represents an important tool for modulating endogenous growth hormone release, with applications ranging from treating GH deficiency to anti-aging and muscle-wasting conditions. Its short half-life and mimicry of natural GH release make it a unique candidate for individuals seeking to enhance GH secretion without the risks of prolonged exposure. However, further clinical studies are needed to evaluate its long-term efficacy and safety.

References:

1. Hansen, T. K., Gravholt, C. H., & Ørskov, H. (2000). GHRH and its analogs: Structure-function relationships and therapeutic implications. Journal of Clinical Endocrinology & Metabolism, 85(12), 4572–4577.
2. Schoeller, A., et al. (2008). Pharmacokinetics of CJC-1295 in humans. Clinical Endocrinology, 68(6), 814–820.
3. Miller, S. A., & Leung, K. C. (2011). Pulsatile growth hormone secretion: Mechanisms and clinical implications. Endocrine Reviews, 32(1), 77-108.
4. Wu, Z., & Jablonka-Shariff, A. (2017). Evaluation of growth hormone releasing hormone analogs: Modified GRF (1-29). Peptides, 88, 34-43.

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