Hexarelin (2mg)

About Hexarelin: Hexarelin is a GH secretagogues (GHSs) or a Growth hormone secretagogues. Also know as Examorelin is a selective synthetic hexapeptide agonist of the growth hormone secretagogue receptor (GHS-R).1,2 It selectively binds to GHS-R over CD36 (IC₅₀s = 15.9 and 2,080 nM, respectively).1 Hexarelin (300 µg/kg, s.c.) increases plasma growth hormone levels in neonatal rats.2 It also improves left ventricular function and reduces fibrosis in a mouse model of myocardial ischemia induced by transient ligation of the left descending coronary artery (LAD) when administered at a dose of 0.3 mg/kg per day.3 Hexarelin had been in phase II clinical trials by for the treatment of growth hormone deficiency and congestive heart failure. However, the researches about this compound candidate were discontinued.

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For more information on hexarelin peptide please visit Pubmed.

References & Product Citations

Product Description References

1. Proulx, C., Picard, É., Boeglin, D., et al. Azapeptide analogues of the growth hormone releasing peptide 6 as cluster of differentiation 36 receptor ligands with reduced affinity for the growth hormone secretagogue receptor 1a. J. Med. Chem. 55(14), 502-511 (2012).

2. Guerlavais, V., Boeglin, D., Mousseaux, D., et al. New active series of growth hormone secretagogues. J. Med. Chem. 46(7), 1191-1203 (2003).

3. McDonald, H., Peart, J., Kurniawan, N.D., et al. Hexarelin targets neuroinflammatory pathways to preserve cardiac morphology and function in a mouse model of myocardial ischemia-reperfusion. Biomed. Pharmacother. 127, 110165 (2020).

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