Hexarelin 2mg

Hexarelin is a GH secretagogues (GHSs) or a Growth hormone secretagogues. Also know as Examorelin is a selective synthetic hexapeptide agonist of the growth hormone secretagogue receptor (GHS-R).1,2 It selectively binds to GHS-R over CD36 (IC₅₀s = 15.9 and 2,080 nM, respectively).1 Hexarelin (300 µg/kg, s.c.) increases plasma growth hormone levels in neonatal rats.2 It also improves left ventricular function and reduces fibrosis in a mouse model of myocardial ischemia induced by transient ligation of the left descending coronary artery (LAD) when administered at a dose of 0.3 mg/kg per day.3 Hexarelin had been in phase II clinical trials by for the treatment of growth hormone deficiency and congestive heart failure.

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For more information on hexarelin peptide please visit Pubmed.

References & Product Citations

Product Description References

1. Proulx, C., Picard, É., Boeglin, D., et al. Azapeptide analogues of the growth hormone releasing peptide 6 as cluster of differentiation 36 receptor ligands with reduced affinity for the growth hormone secretagogue receptor 1a. J. Med. Chem. 55(14), 502-511 (2012).

2. Guerlavais, V., Boeglin, D., Mousseaux, D., et al. New active series of growth hormone secretagogues. J. Med. Chem. 46(7), 1191-1203 (2003).

3. McDonald, H., Peart, J., Kurniawan, N.D., et al. Hexarelin targets neuroinflammatory pathways to preserve cardiac morphology and function in a mouse model of myocardial ischemia-reperfusion. Biomed. Pharmacother. 127, 110165 (2020).

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