What is Tesofensine?, The All In One Fat Loss Compound

If you’re like most people, you’re probably always on the lookout for new and better ways to lose weight. And with obesity rates skyrocketing all over the world, it’s no wonder why. But despite all of our best efforts, sometimes losing weight can seem like an impossible task.

Enter Teseofensine. This new and innovative compound is safe and effective in animal models and has also been shown to cause unintended weight loss in obese patients with Parkinson’s or Alzheimer’s disease. In short, Teseofensine could be the key to finally achieving your weight loss goals.

Tesofensine (NS2330) is classified as a presynaptic serotonin-noradrenaline-dopamine reuptake inhibitor. This means that it prevents the reabsorption of these three neurotransmitters by the central nervous system. When tesofensine is present, the body feels less hungry.

Tesofensine acts primarily as an appetite suppressant with simultaneous effects on fat oxidation and resting energy expenditure. Tesofensine also has a modulating action on dopamine in a particular section of the brain which appears to affect the pleasure sensation of food consumption. As a result, tesofensine can help with weight loss by reducing hunger and by making food less pleasurable.

Mechanism of Action

So how does Teseofensine work? The research compound works by inhibiting the presynaptic inhibition a process where the release of neurotransmitters is reduced by blocking their vesicular transport or chelation within the presynaptic nerve terminal. This can be done in many ways including, but not limited to, administrating compounds that block synaptic vesicle recycling, such as Teseofensine. Although the full mechanism of Teseofensine is unknown, it is speculated that the drug works by inhibiting VMAT2 function and subsequent dopamine uptake. This reduces dopaminergic tone in the nigrostriatal pathway and ultimately leads to a reduction in Parkinson-related symptoms.

Tesofensine results in clinical trials

In human trials, tesofensine is an effective weight-loss compound. One trial found that tesofensine resulted in an average weight loss of 5.8 kg over a 24-week period, compared to a placebo group which only lost an average of 1.4 kg.

Tesofensine is a triple monoamine reuptake inhibitor which slows down the removal of noradrenaline, 5-HT and dopamine. This compound has been shown in animal models to have an appetite suppressant effect due at least partially because it blocks central dopamine receptors’ function after they’ve been blocked by excess weight gain surrounding these cells; this discovery could open up new possibilities for how we treat obesity without resorting back into surgery or other procedures that are often ineffective