TB-500 (Thymosin Beta 4) 2MG

$29.99

TB 500 for sale is available in lyophilized powder form, in 2mg vials.

SKU: tb-500 Category: Tag:

Description

About TB-500: Thymosin β4 is an actin-sequestering peptide that has wound healing and anti-inflammatory activities.1,2,3 It regulates cytoskeletal rearrangement by binding to actin (Kds = 0.7 and 2.1 µM for human platelets and rabbit muscle, respectively) and inhibiting the polymerization of actin monomers.1

Thymosin β4 increases in vitro migration of human umbilical vein endothelial cells (HUVECs), keratinocytes, and coronary artery endothelial cells, but not fibroblasts, actin smooth muscle cells, neutrophils, monocytes, or HT-1080 fibrosarcoma cells, when used at concentrations ranging from 0.001 to 1 µg/ml.2,4

It increases gap closure and reduces wound width in a rat full-thickness cutaneous wound model when administered at a dose of 60 µg.2 Thymosin β4 (1 µg/ml) inhibits TNF-α-induced NF-ĸB phosphorylation and nuclear translocation in immortalized human corneal epithelial cells and decreases the expression of chemokine (C-X-C motif) ligand 1 (CXCL1), CXCL2, matrix metalloproteinase-9 (MMP-9), and MMP-2 in the cornea in a mouse model of sodium hydroxide-induced corneal injury when administered at a dose of 5 µg.3

BUY TB-500 Today from GenX Peptides.

We offer the highest grade and purity of TB-500 for sale at a competitive price in the USA. For best results buy TB-500 peptides of the highest quality from GenX Peptides.

For more information on TB-500 peptide please visit Pubmed.

References & Product Citations

Product Description References

1. Weber, A., Nachmias, V.T., Pennise, C.R., et al. Interaction of thymosin β4 with muscle and platelet actin: Implications for actin sequestration in resting platelets. Biochemistry 31(27), 6179-6185 (1992).

2. Malinda, K.M., Sidhu, G.S., Mani, H., et al. Thymosin β4 accelerates wound healing. J. Invest. Dermatol. 113(3), 364-368 (1999).

3. Sosne, G., Qiu, P., Christopherson, P.L., et al. Thymosin beta 4 suppression of corneal NFκB: A potential anti-inflammatory pathway. Exp. Eye Res. 84(4), 663-669 (2007).

4. Malinda, K.M., Goldstein, A.L., and Kleinman, H.K. Thymosin β4 stimulates directional migration of human umbilical vein endothelial cells. FASEB J. 11(6), 474-481 (1997).

Unit Size2 mg/vial
Unit Quantity1 Vial
Molecular FormulaC212H350N56O78S
Molecular Weight4963.44
SequenceAc-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr- Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser-OH
AppearanceWhite Powder
Peptide Purity>99%
Solubility>Soluble in water or 1% acetic acid
Identity (ESI-MS)4963.44±5.1
SourceChemical Synthesis
StorageLyophilized TB-500 (Thymosin Beta 4) is stable at room temperature for 90 days. However, it should be stored in a freezer below -8C for any extended period.
Safety InformationFor Research Only. Not Intended for Diagnostic or Therapeutic Use.

 

Additional information

Weight1 oz
Dimensions1 × 1 × 1 in
TB500 Peptide Vial
TB-500 (Thymosin Beta 4) 2MG
$29.99
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