HGH, or Human Growth Hormone, is a hormone produced by the pituitary gland, which rests at the center of the human brain. It is in charge of physical growth, particularly growth spurts in babies and adolescents. In addition to this, HGH regulates body fluids, internal chemical compositions, muscle and bone growth, metabolism, and heart function. (1, 2)
What is HGH Fragment 176-191?
HGH, or hGH, is a hormone, which means that it is composed of a series of amino acids bonded together in a specific structure. The 176-191 amino acid fragment of hGH is also known as somatropin and is often noted as hGH (176-191). This fragment is a modified version of amino acids 176-191 found at the C-terminal region of hGH. It makes up just under 10% of the Human Growth Hormone and has been the subject of modern research and debate for years.
Why Is HGH Fragment 176-191 Important/Useful/What Used For
HGH (176-191) stimulates the breakdown of fat, or lipolysis, and inhibits the development of fat, or lipogenesis. It is more in-demand than full-form HGH because it has been proven to be 12.5 times stronger than regular HGH. Studies have shown hGH (176-191) to help reduce body fat content and aid in weight loss.
Additionally, hGH (176-191) can help increase muscle mass, improve skin texture, reduce wrinkles, and eliminate cellulite, especially in women; studies prove that somatropin supplements are effective in promoting all of these processes. (3, 4)
New Research HGH Fragment 176-191 (Somatropin)
Somatropin, or hGH (176-191), has been under the microscope for decades. Research on the hGH fragment began in 1963 and has made significant progress since then.
Somatropin to Treat Growth Failure in Children
Somatropin has been used to treat growth failure in children since the early 1960s; it is still used for this purpose and is widely seen as a prescription for people with Noonan syndrome, Turner syndrome, Prader-Willi syndrome, and others.
Somatropin for Turner Syndrome in Adolescent Girls
hGH (176-191) was approved as a treatment for Turner syndrome in 1996 by the Food and Drug Administration (FDA) in the United States. However, new research shows that girls experiencing short height due to Turner Syndrome do not experience it because of lack of hGH, but due to insufficient estradiol levels. This proves that while hGH is in charge of encouraging growth in children, particularly young girls, it is not the only factor. (5)
Somatropin for Bone Health
HGH is largely associated with longitudinal growth and height, especially in pubescent individuals. Deficiencies can lead to stunted height and can hinder bone growth and elongation. This concept was first contemplated in 1921 by Evans and Long. It was later proven that this was indeed the case; various studies were then conducted to define the mode of action of hGH, Somatropin, and related hormones on bone development. (6)
hGH (176-191) is vital for bone health, especially in young people whose bones have not yet developed. Somatropin levels directly impact bone mass and growth rate. (7) Somatropin works by aiding in new bone formation by osteoblasts and bone resorption by osteoclasts. hGH works by directly, and also with the help of IGF-I, stimulating osteoclast activity. In turn, bone resorption is promoted. The final result is an improved rate of bone remodeling; bone remodeling refers to the process of new bone formation. There is also a gradual loss of bone mineral density as the bone matures.
A sharp, unnatural, premature decline in HGH levels leads to a reduction in bone health and density; as a result, the bone may become brittle, or remain stunted. hGH (176-191) can help reverse this by regulating osteoclast activity and osteoblast development into bone tissue and associated matrices. (8, 9)
Somatropin for Weight Regulation and Fat Reduction
hGH (176-191) can effectively curb weight gain and reduce the amount of stored adipose tissue in the human body. However, scientists cannot claim that somatropin supplements are safe to use in the long run; excessive use of such hormonal supplements may prove to have unwanted side effects including carpal tunnel syndrome, muscle or joint pain, numbness or tingling sensations in the skin, cancerous growths due to excessive growth hormone in the body, unnaturally high levels of cholesterol in the body and blood, swelling, fluid retention and edema, and an increased risk of heart disease or, in some cases, diabetes.
While not a steroid, HGH supplements certainly can have a similar effect if not taken in regulated quantities. There is still insufficient research to prove that somatropin supplements are entirely safe to take for long-term durations.
In terms of fat loss, many papers have shown positive results. Despite this, safety cannot be guaranteed. However, it has been noted that somatropin or hGH (176-191) supplements can reduce internal fat content in obese mice. (10) As far as the mode of action is concerned, somatropin works by increasing the rate of fat oxidation and hence “burns” away fat in obese bodies. A similar effect is seen in human bodies, too.
GenX Peptides | Conclusion
There are many positive uses associated with hGH fragment 176-191, including weight loss, body fat regulation, repair of bone density, combatting stunted growth, and improving skin texture. However, despite decades of research, it cannot be claimed that somatropin supplements are entirely safe to take. Regardless, they can certainly be used to treat certain conditions, like Noonan syndrome, and fix the body’s HGH imbalance.
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